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- OECD 431 - Human Skin Corrosion: "In Vitro OECD 431: Reconstructed Human Epidermis Test Method, in vitro Test - Skin Corrosion in the regulatory hazard classification and labeling context is defined as the production of irreversible damage to skin, generally evident as necrosis through the epidermis and into the dermis, following a defined chemical exposure. The In Vitro Skin Corrosion Test is an in vitro, non-animal test designed to identify those chemicals and mixtures capable of inducing skin corrosion (UN GHS Category 11), and in some cases to partially subcategorize corrosives into UN GHS Sub-Categories 1A or 1B and 1C (ie., the current test methods do not effectively discriminate between UN GHS Sub-Categories 1B and 1C). For more information please contact INVITRO-CONNECT GmbH for assistance in developing specialized protocols for your test materials. INVITRO-CONNECT GmbH: Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com

We offer you the following services: - Regulatory Advice - REACH Registration - Preparation of Registration Dossiers - Read Across - IUCLID - Robust Study Summaries - Chemical Safety Report / CSR - Toxicological Expertise - Optimal Test Strategy Development - REACH Testing: Tests and Studies acc. GLP - REACH Study Monitoring - SVHC Screening - Risk Assessment - REACh Compliance Service / REACh Auditing Service - REACH Material Safety Data Sheets We would also be happy to be your REACH service provider, who reliably looks after your REACH projects, just as we already do for many other satisfied customers. For more information please contact INVITRO-CONNECT GmbH. Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com REACH Service - All REACH laboratory tests - Phys-Chem / Tox / in vitro tests / Genotox / Ecotox, etc. - More than 80 test laboratories - Study monitoring, Regulatory Service, IUCLID 6, CSR etc.

- OECD 439 / Skin Irritation Test (SIT) in a Reconstructed Human Epidermis (RhE) Model - Skin Irritation in the regulatory hazard classification and labeling context is defined as the production of reversible damage to skin following a defined chemical exposure. The Skin Irritation Test (SIT) is an in vitro, non-animal test designed to identify those chemicals and mixtures capable of inducing moderate skin irritation (UN GHS Category 2 Skin Irritants1), and to discriminate UN GHS Category 2 Skin Irritants from UN GHS 3 Mild Skin Irritants as well as those not requiring classification for skin irritation potential. INVITRO-CONNECT GmbH has extensive expertise with a wide variety of reconstructed skin-based protocols. For more information please contact INVITRO-CONNECT GmbH for assistance in developing specialized protocols for your test materials. INVITRO-CONNECT GmbH: Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com

Our experts support you with the following services: - Toxicological assessment within the framework of the REACH and biocide regulations - Environmental Risk Assessment (ERA = Environmental Impact Assessment), e.g. for pharmaceuticals - Literature research and evaluation - Examination of the reliability and validity of the studies carried out (according to OECD guidelines, EU methods or according to Klimisch et al. 1997) - Assessment of relevant toxicological endpoints, e.g. acute toxicity, genotoxicity, irritation / corrosion of the skin or eyes - Evaluation of all relevant toxicological, ecotoxicological endpoints, e.g. freshwater organisms (daphnia, algae, fish) - Read Across - Study monitoring of studies - Creation of the Endpoint Summaries and Endpoint Study Records for IUCLID (REACH and biocidal active ingredients and products) - Safety assessment and safety report for cosmetic products - Water hazard class - etc. Questions?--> contact@invitro-connect.com

NVITRO-CONNECT GmbH is your ideal partner and service provider for your projects in the field of life science for chemicals / REACH, pharmaceuticals, biocides, cosmetics and medical devices. We are the strong partner at your side who provides our tailor-made service modules according to your project requirements. You have the choice to individually select the modules that you urgently need in your projects from our modular service system. With our technical expertise and our customer-oriented approach, we fit in perfectly with your projects and processes, so that we form a team and nothing stands in the way of the project's success. The Modules can be individually and flexibly adapted for each project. For more information please contact INVITRO-CONNECT GmbH. INVITRO-CONNECT GmbH - Your International Experts for Laboratory Testing and Regulatory Services Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com

- in vitro gene mutation study in bacteria: Ames Test OECD 471 - in vitro gene mutation study in mammalian cells: Mouse Lymphoma Assay (MLTK Assay) OECD 490 - in vitro gene mutation study in mammalian cells: HPRT test / OECD 476 - Micronucleus Assay in vitro (Human Lymphocytes or V79 cells) / OECD 487 - Chromosomal aberration Assay in vitro (Human Lymphocytes or V79 cells) / OECD 473 - Hen’s Egg Test – Induction of Micronuclei (HET-MN) - COMET Assay in different cell types - Cell Transformation Assay in Bhas Cells / OECD 231 (draft) - Mammalian Erythrocyte Micronucleus Test / OECD 474 / ISO 10993-3 - Combined Mammalian Erythrocyte Micronucleus Test with concurrent Alkaline Comet Assay in vivo OECD 474 & 489 - In vivo Mammalian Alkaline Comet Assay / OECD 489 - Unscheduled DNA synthesis (UDS) Test with Mammalian Liver Cells in vivo / OECD 486 - Mammalian Spermatogonial Chromosomal Aberration test / OECD 483 - Mammalian Bone Marrow Chromosomal Aberration test / OECD 475

INVITRO-CONNECT GmbH - Massgeschneiderte Dienstleistungen im Bereich Life Science - Ihre internationalen Experten für Labortests und Regulatorische Dienstleistungen - Profitieren Sie von einem internationalen, sehr gut organisierten Netzwerk: sorgfältig ausgewählte Experten, in house - Toxikologen und mehr als 80 akkreditierte Prüflabore und Dienstleister mit über 20 Jahren Erfahrung in der Branche. Wir sind ihr kompetenter Partner für Regulatorische- und Toxikologische Fragestellungen, Experten Dienstleistungen, Gutachten und alle OECD - Labortests zu Rechtsvorschriften wie: - REACH-Verordnung - Biozid-Verordnung - GHS/CLP-Verordnung - Kosmetik-Verordnung - Medizinprodukte-Verordnung - Tierarzneimittel-Verordnung - Arzneifuttermittel-Verordnung - Pestizide u. Pflanzenschutzmittel-Verordnung - Arzneimittel-Verordnung Gerne sind wir Ihr zuverlässiger Partner für ihre Labordienstleistungen und Regulatorischen Projekte. Dr. Ute Hassmann (Deputy Managing Director)

INVITRO-CONNECT GmbH - Massgeschneiderte Dienstleistungen im Bereich REACH - Ihre internationalen Experten für Labortests und Regulatorische Dienstleistungen - Profitieren Sie von einem internationalen, sehr gut organisierten Netzwerk: sorgfältig ausgewählte Experten, in house - Toxikologen und mehr als 80 akkreditierte Prüflabore und Dienstleister mit über 20 Jahren Erfahrung in der Branche. Wir sind ihr kompetenter Partner für Regulatorische- und Toxikologische Fragestellungen, Experten Dienstleistungen, Gutachten und alle OECD - Labortests zur Umsetzung der EU-Richtlinie REACH (Registration, Evaluation and Authorisation of Chemicals) Gerne sind wir Ihr zuverlässiger Partner für ihre Labordienstleistungen und Regulatorischen Projekte. Dr. Ute Hassmann (Deputy Managing Director) Alle REACH-Labortests - Phys-Chem / Tox / in vitro Tests / Genotox / Ökotox etc. - Mehr als 80 Prüflabore - Persönliche Projektbetreuung - Study Monitoring, IUCLID 6, Dossiererstellung etc.